 U.S. Attorney General: Alberto Gonzales, 2005 - present
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 U.S. Secretary of Housing and Urban Development: Henry Cisneros, 1993 - 1997
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 U.S. Surgeon General: Antonia Coello Novello, 1990–1993
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 U.S. Secretary of Transportation: Federico Peña, 1993
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U.S. Treasurer: Romana Acosta Bańuelos, 1971–1974
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U.S. Senator: Dennis Chávez, 1935 – 1962
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U.S. Congressman: Joseph Marion Hernández, Florida territory, 1822 - 1823
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U.S. Representative: Romualdo Pacheco, California, 1877 - 1878
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